https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 Heritable defects in telomere and mitotic function selectively predispose to sarcomas https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50526 Wed 28 Feb 2024 15:27:25 AEDT ]]> Homologous recombination DNA repair defects in PALB2-associated breast cancers https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45235 Wed 26 Oct 2022 19:59:05 AEDT ]]> Lynch syndrome testing of colorectal cancer patients in a high-income country with universal healthcare: a retrospective study of current practice and gaps in seven australian hospitals https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51759 70 years). Of 38 patients with high-risk tumour test results and genetics services referral, diagnostic testing was carried out for 25 (89%) and identified a LS pathogenic/likely pathogenic variant for 11 patients (44% of 25; 0.7% of 1,624 patients). Conclusions: Given the LS testing and referral gaps, further work is needed to identify strategies for successful integration of LS testing into clinical care, and provide a model for hereditary cancers and broader genomic medicine. Standardised reporting may help clinicians interpret tumour test results and initiate further actions.]]> Wed 13 Mar 2024 08:10:01 AEDT ]]>